Modern clinical trials generate reams of data from multiple sources, creating enormous information management challenges for sponsors. Today, the growing popularity of decentralized clinical trials (DCTs) only exacerbates the problem. It is not enough to cobble together multiple management systems; these new approaches to trials require new clinical trial management systems (CTMS). A modern CTMS must organize and centralize issue management thereby simplifying trial oversight and increasing sponsor efficiency. This “unified approach” is at the core of the Remarque Systems platform.